News Details

Tempus Reports Third Quarter 2026 Results

November 2, 2026

Tempus AI, Inc. (NASDAQ: TEM), a technology company leading the adoption of AI to advance precision medicine, today reported financial results for the quarter ended September 30, 2026.

“Q3 was another record quarter, as we delivered $411.5 million of revenue, led by accelerating unit growth of 32% in our oncology business and increasing momentum of 33% revenue growth in Data & Applications,” said Eric Lefkofsky, founder and CEO of Tempus. “These results reinforce the durability of our model as our best-in-class diagnostic platform enhances our data and AI offerings, distinguishes our business from our many competitors, and helps drive our performance quarter after quarter.”

Third Quarter 2026 Highlights

For the three-month period ended September 30, 2026, as compared to the same period in 2025:

  • Total revenue of $411.5 million, an increase of 23%
    • Oncology volume growth accelerated to 32%
    • Minimal Residual Disease (MRD) volume of ~12,000 tests, up 300%
    • Data & Apps revenue increased 33%, with Insights increasing 29%
  • Increasing full year 2026 revenue guidance to $1.60 to $1.605 billion and expect full year Adjusted EBITDA of ~$65 million
  • Announced multi-year strategic collaboration with Merck and Moderna to support commercialization of their individualized neoantigen therapy (INT) class of drugs
  • In October, announced a strategic collaboration with BMS bringing Tempus’ total data licensing bookings to >$550 million year to date

Third Quarter 2026 Summary Results

For the three-month period ended September 30, 2026, as compared to the same period in 2025:

  • Total revenue increased 23% to $411.5 million.
    • Diagnostics generated $303.5 million of revenue, representing 20% growth, driven by Oncology volume growth of 32%, offset by Hereditary revenue growth of 3%.
    • Data and Applications generated $108.1 million of revenue, representing 33% growth, with Insights growing 29%.
  • Gross profit increased 27% to $266.7 million, led by growth in Data and Applications.
  • Net loss was $(14.9) million, which included $50.8 million of stock-based compensation expense and related employer payroll taxes and $42.8 million in unrealized gains on marketable securities, compared to a net loss of $(80.0) million in Q3 of 2025.
  • Adjusted EBITDA was $25.6 million, compared to $1.5 million in Q3 of 2025.
  • Ended the quarter with cash and marketable securities of $854.4 million.

Detailed Operational Highlights

  • Announced a strategic collaboration with BMS in October through which Tempus is directly licensing to BMS oncology data and models for up to $137.5 million over a five-year term. In addition, BMS and Pathos are licensing data for patients with Alzheimer's or dementia for $55 million over a five-year term, extending Tempus’ data and modeling platform beyond oncology.
  • Announced a multi-year strategic collaboration with Merck and Moderna to support the potential commercialization of intismeran autogene, a novel, potential first-in-class individualized neoantigen therapy (INT) being evaluated in combination with KEYTRUDA (pembrolizumab), Merck’s anti-PD-1 therapy, in patients with completed resected stage IIB-IV melanoma and other cancer types.
  • Cleared regulatory review of pending acquisition of Personalis (Nasdaq: PSNL). Personalis' shareholder meeting to approve the acquisition is planned for November 30, 2026.
  • Received two 510(k) clearances from the U.S. Food and Drug Administration (FDA) for Tempus ECG-PH and ECG-MR, expanding our non-invasive AI cardiology footprint.
  • Announced an initiative to build a research platform containing 100,000 whole genomes linked to longitudinal clinical information over the next several years.

Third Quarter Financial Results

Three Months Ended September 30,

2026

2025

Change

(in thousands, except percentages and per share amounts)

(unaudited)

Revenue

$

411,537

$

334,206

23

%

Gross profit

$

266,701

$

209,942

27

%

Loss from operations

$

(56,864

)

$

(60,996

)

7

%

Non-GAAP income (loss) from operations

$

14,422

$

(8,662

)

267

%

Net loss

$

(14,851

)

$

(79,982

)

81

%

Non-GAAP net income (loss)

$

13,359

$

(19,590

)

168

%

Adjusted EBITDA

$

25,572

$

1,476

1,633

%

Net loss per share, basic and diluted

$

(0.08

)

$

(0.46

)

83

%

Non-GAAP net income (loss) per share, basic and diluted

$

0.07

$

(0.11

)

164

%

Financial Outlook and Guidance

Tempus is increasing its full year 2026 revenue guidance to $1.60 to $1.605 billion, which represents ~25% annual growth. We continue to expect 2026 Adjusted EBITDA to be ~$65 million.

For additional information on the quarter, including a letter from our CEO and CFO, please visit our investor relations site at investors.tempus.com.

Webcast and Conference Call Information

A conference call and webcast will begin today, November 2, 2026 at 8:45 a.m. Eastern Time. Interested parties may access details at:

Conference ID: 579 261 752
United States (Toll-Free): (833) 461-5787
International (Toll): +1 (585) 542-9983
Live webcast can be accessed here

The webcast may be accessed on the company’s investor relations website at investors.tempus.com. For those unable to listen to the live webcast, a recording will be made available on the company’s website after the event and will be accessible for one year. Visit the investor relations website to find the company’s latest deck, and commentary on the quarter by Eric Lefkofsky, Founder and CEO, and Jim Rogers, CFO, which will be discussed on the conference call and webcast.

About Tempus

Tempus is a technology company making precision medicine a reality through the practical application of artificial intelligence in healthcare. With one of the world’s largest libraries of de-identified multimodal data and an intelligent operating system that makes that data accessible and actionable, Tempus connects AI, diagnostics and clinical workflows to deliver more personalized patient care and accelerate the discovery, development and delivery of better medicines. By continuously transforming data into insights, Tempus is building a learning healthcare ecosystem in which every patient can benefit from the treatment and experiences of those who came before.

For more information, visit tempus.com and follow Tempus on LinkedIn, Instagram, and X.

Non-GAAP Financial Measures

In addition to the financial information presented in this release in accordance with accounting principles generally accepted in the United States of America (GAAP), Tempus also presents adjusted non-GAAP financial measures.

Non-GAAP gross profit is defined as GAAP gross profit, excluding stock-based compensation expense and employer payroll tax related to stock-based compensation (collectively, the “stock-based compensation adjustments”). Non-GAAP gross margin is defined as gross profit, excluding the stock-based compensation adjustments, as a percentage of revenue. Non-GAAP operating expenses are calculated as the sum of technology research and development expense, research and development expense, and selling, general and administrative expense, excluding the stock-based compensation adjustments, acquisition-related expenses, amortization of intangibles due to acquisition, and franchise taxes related to IPO. Non-GAAP income (loss) from operations is defined as loss from operations, adjusted to exclude (i) the stock-based compensation adjustments, (ii) acquisition-related expenses, (iii) franchise taxes related to IPO, and (iv) amortization of intangibles due to acquisition. Non-GAAP net income (loss) is defined as net loss, adjusted to exclude (i) changes in fair value of our marketable equity securities and indemnity-related holdback liabilities, (ii) the stock-based compensation adjustments, (iii) acquisition-related expenses, (iv) amortization of intangibles due to acquisition, (v) losses (gains) from equity method investments, (vi) provision for (benefit from) income taxes, (vii) franchise taxes related to IPO, (viii) amortization of deferred other income from our IP License Agreement with SB Tempus, and (ix) loss on debt extinguishment. Non-GAAP net income (loss) per share is defined as non-GAAP net income (loss) divided by weighted average common shares outstanding, basic and diluted.

Adjusted EBITDA is defined as net loss, adjusted to exclude (i) interest income, (ii) interest expense, (iii) depreciation and amortization, (iv) provision for (benefit from) income taxes, (v) losses (gains) from equity method investments, (vi) changes in fair value of our marketable equity securities and indemnity-related holdback liabilities, (vii) the stock-based compensation adjustments, (viii) acquisition-related expenses, (ix) amortization of deferred other income from our IP License Agreement with SB Tempus, (x) franchise taxes related to our IPO, and (xi) loss on debt extinguishment.

Tempus believes these non-GAAP financial measures are useful to investors and others because they allow for additional information with respect to financial measures used by management in its financial and operational decision-making and they may be used by institutional investors and the analyst community to help them analyze the health of Tempus’ business. In particular, Adjusted EBITDA is a key measurement used by Tempus management to make operating decisions, including those related to analyzing operating expenses, evaluating performance, and performing strategic planning and annual budgeting. However, there are a number of limitations related to the use of non-GAAP financial measures, and these non-GAAP measures should be considered in addition to, not as a substitute for or in isolation from, our financial results prepared in accordance with GAAP. Other companies, including companies in our industry, may calculate these non-GAAP financial measures differently or not at all, which reduces their usefulness as comparative measures.

Tempus does not provide guidance for net loss, the most directly comparable GAAP measure to Adjusted EBITDA, and similarly cannot provide a reconciliation between Tempus’ forecasted Adjusted EBITDA and net loss without unreasonable effort due to the unavailability of reliable estimates for certain components of net loss and the respective reconciliations. These forecasted items are not within Tempus’ control, may vary greatly between periods, and could significantly impact future financial results.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended, about Tempus and its industry that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this press release are forward-looking statements, including, but not limited to, Tempus’ expected financial results for full year 2026; expectations concerning Tempus' collaborations and partnerships; Tempus' competitive position; and the pending acquisition of Personalis. In some cases, you can identify forward-looking statements because they contain words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “going to,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” or the negative of these words or other similar terms or expressions. Tempus cautions you that the foregoing may not include all of the forward-looking statements made in this press release.

You should not rely on forward-looking statements as predictions of future events. Tempus has based the forward-looking statements contained in this press release primarily on its current expectations and projections about future events and trends that it believes may affect Tempus’ business, financial condition, results of operations and prospects. These forward-looking statements are subject to risks and uncertainties related to: the intended use of Tempus’ products and services; Tempus’ financial performance; the ability to attract and retain customers and partners; managing Tempus’ growth and future expenses; competition and new market entrants; compliance with new laws, regulations and executive actions, including any evolving regulations in the artificial intelligence space; the ability to maintain, protect and enhance Tempus’ intellectual property; the ability to attract and retain qualified team members and key personnel; the ability to repay or refinance outstanding debt, or to access additional financing; future acquisitions, divestitures or investments, including Tempus' ability to consummate the acquisition of Personalis on the contemplated terms or at all and Tempus’ ability to realize the expected benefits of the acquisition of Paige AI, Ambry Genetics, Deep 6 AI, Center Health, and, if consummated, Personalis; the potential adverse impact of climate change, natural disasters, health epidemics, macroeconomic conditions, and war or other armed conflict, as well as risks, uncertainties, and other factors described in the section titled “Risk Factors” in Tempus’ Form 10-K for the year ended December 31, 2025, filed with the Securities and Exchange Commission (the "SEC") on February 24, 2026, as well as in other filings Tempus may make with the SEC from time to time. In addition, any forward-looking statements contained in this press release are based on assumptions that Tempus believes to be reasonable as of this date. Tempus undertakes no obligation to update any forward-looking statements to reflect events or circumstances after the date of this press release or to reflect new information or the occurrence of unanticipated events, except as required by law.

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

(Unaudited)

(in thousands, except per share amounts)

Three Months Ended September 30,

Nine Months Ended September 30,

2026

2025

2026

2025

Net revenue

Diagnostics(1)

$

303,470

$

252,878

$

853,901

$

688,525

Data and applications(2)

108,067

81,328

288,238

216,053

Total net revenue

$

411,537

$

334,206

$

1,142,139

$

904,578

Cost and operating expenses

Cost of revenues, diagnostics

114,042

98,643

323,235

283,182

Cost of revenues, data and applications

30,794

25,621

83,664

61,212

Technology research and development

45,708

38,087

135,558

105,960

Research and development

46,000

44,960

146,874

122,453

Selling, general and administrative

231,857

187,891

670,296

523,230

Total cost and operating expenses

468,401

395,202

1,359,627

1,096,037

Loss from operations

$

(56,864

)

$

(60,996

)

$

(217,488

)

$

(191,459

)

Interest income

3,985

4,600

11,748

7,506

Interest expense

(6,701

)

(15,399

)

(31,325

)

(54,981

)

Loss on debt extinguishment

—

(12,034

)

(11,643

)

(12,034

)

Other income, net(3)

47,132

2,605

122,180

16,879

Loss before (provision for) benefit from income taxes

$

(12,448

)

$

(81,224

)

$

(126,528

)

$

(234,089

)

(Provision for) benefit from income taxes

(35

)

(276

)

(282

)

45,692

(Losses) gains from equity method investments

(2,368

)

1,518

(8,318

)

(2,465

)

Net loss

$

(14,851

)

$

(79,982

)

$

(135,128

)

$

(190,862

)

Net loss per share, basic and diluted

$

(0.08

)

$

(0.46

)

$

(0.75

)

$

(1.10

)

Weighted-average shares outstanding used to compute net loss per share, basic and diluted

181,311

174,945

180,049

172,969

Comprehensive loss, net of tax

Net loss

$

(14,851

)

$

(79,982

)

$

(135,128

)

$

(190,862

)

Foreign currency translation adjustment

2,107

(2,915

)

(736

)

5,439

Comprehensive loss

$

(12,744

)

$

(82,897

)

$

(135,864

)

$

(185,423

)

(1) Includes related party revenue from Pathos AI, Inc. of $0 and $225 for the three months ended September 30, 2026 and 2025, respectively. Includes related party revenue from Pathos AI, Inc. of $190 and $226 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 16, Related Parties.

(2) Includes related party revenue from Pathos AI, Inc. of $22,061 and $24,907 for the three months ended September 30, 2026 and 2025, respectively. Includes related party revenue from Pathos AI, Inc. of $65,718 and $41,445 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 16, Related Parties. Also includes related party revenue from SB Tempus Corp. of $0 and $6,253 for the three months ended September 30, 2026 and 2025, respectively. Includes related party revenue from SB Tempus Corp. of $6,241 and $18,743 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 7, Joint Venture.

(3) Includes related party other income from SB Tempus Corp. of $3,989 for each of the three months ended September 30, 2026 and 2025. Includes related party other income from SB Tempus Corp. of $11,966 for each of the nine months ended September 30, 2026 and 2025. Refer to Note 7, Joint Venture.

Tempus AI, Inc.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)

(in thousands, except share and per share amounts)

September 30, 2026

December 31, 2025

Assets

Current Assets

Cash and cash equivalents

$

590,479

$

604,787

Accounts receivable(1), net of allowances of $4,378 and $2,755 at September 30, 2026 and December 31, 2025, respectively

380,744

311,170

Inventory

53,773

51,724

Related party asset

17,500

8,785

Prepaid expenses and other current assets

47,507

40,498

Marketable equity securities

46,874

150,211

Total current assets

$

1,136,877

$

1,167,175

Property and equipment, net

95,186

89,156

Goodwill

488,142

470,211

Intangible assets, net

293,815

349,202

Capitalized software, net

40,561

6,051

Marketable equity securities, less current portion

212,276

—

Investments and other assets

16,241

21,111

Investment in joint venture

77,635

86,557

Investment in related party

17,500

—

Related party asset, less current portion

10,208

16,215

Operating lease right-of-use assets

58,402

64,496

Restricted cash

4,755

4,664

Total Assets

$

2,451,598

$

2,274,838

Liabilities, Convertible redeemable preferred stock, and Stockholders' equity

Current Liabilities

Accounts payable

70,506

81,994

Related party payable

10,000

—

Accrued expenses

232,976

155,370

Deferred revenue(2)

85,931

92,673

Deferred other income(3)

11,966

15,955

Other current liabilities

12,146

8,680

Operating lease liabilities

11,584

13,355

Accrued data licensing fees

1,296

4,361

Total current liabilities

$

436,405

$

372,388

(1) Includes related party accounts receivable from Pathos AI, Inc. of $12,092 and $6,428 as of September 30, 2026 and December 31, 2025, respectively. Refer to Note 16, Related Parties. Also includes related party accounts receivable from SB Tempus Corp. of $318 and $173 as of September 30, 2026 and December 31, 2025, respectively. Refer to Note 7, Joint Venture.

(2) Includes related party deferred revenue from Pathos AI, Inc. of $103 and $3,938 as of September 30, 2026 and December 31, 2025, respectively. Refer to Note 16, Related Parties. Also includes related party deferred revenue from SB Tempus Corp. of $0 and $6,235 as of September 30, 2026 and December 31, 2025, respectively. Refer to Note 7, Joint Venture.

(3) Deferred other income balances solely related to SB Tempus Corp. Refer to Note 7, Joint Venture.

Tempus AI, Inc.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)

(in thousands, except share and per share amounts)

September 30, 2026

December 31, 2025

Operating lease liabilities, less current portion

69,483

74,272

Convertible promissory note

175,967

208,672

Other long-term liabilities

51,449

56,600

Revolving credit facility

—

100,000

Interest payable

22,501

12,393

Long-term debt, net

—

202,753

Convertible senior notes, net

1,174,877

728,078

Deferred other income, less current portion(3)

—

7,977

Deferred revenue, less current portion

20,514

20,379

Total Liabilities

$

1,951,196

$

1,783,512

Commitments and contingencies (Note 8)

Convertible redeemable preferred stock, $0.0001 par value, 20,000,000 shares authorized at September 30, 2026 and December 31, 2025, respectively, no shares outstanding at September 30, 2026 and December 31, 2025

$

—

$

—

Stockholders' equity

Class A Common Stock, $0.0001 par value, 1,000,000,000 shares authorized at September 30, 2026 and December 31, 2025, respectively; 177,182,062 and 173,235,428 shares outstanding at September 30, 2026 and December 31, 2025, respectively

18

17

Class B Common Stock, $0.0001 par value, 5,500,000 shares authorized at September 30, 2026 and December 31, 2025, respectively; 5,043,789 outstanding at September 30, 2026 and December 31, 2025, respectively

1

1

Treasury Stock, 203,431 and 183,229 shares at September 30, 2026 and December 31, 2025, respectively, at cost

(6,642

)

(6,642

)

Additional paid-in capital

3,037,849

2,892,910

Accumulated other comprehensive income

166

902

Accumulated deficit

(2,530,990

)

(2,395,862

)

Total Stockholders' equity

$

500,402

$

491,326

Total Liabilities, Convertible redeemable preferred stock, and Stockholders' equity

$

2,451,598

$

2,274,838

(3) Deferred other income balances solely related to SB Tempus Corp. Refer to Note 7, Joint Venture.

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands)

Nine Months Ended
September 30,

2026

2025

Operating activities

Net loss

$

(135,128

)

$

(190,862

)

Adjustments to reconcile net loss to net cash used in operating activities

Stock-based compensation

154,901

79,408

Gain on marketable equity securities

(108,939

)

(4,731

)

Loss on disposal of property and equipment

375

—

Deferred income taxes

—

(46,216

)

Losses from equity method investments

8,318

2,465

Amortization of original issue discount

5,008

2,615

Amortization of deferred financing fees

260

398

Change in fair value of holdback liability

1,189

291

Loss on debt extinguishment

11,643

12,034

Depreciation and amortization

78,392

75,416

Provision for bad debt expense

2,450

767

Provision for obsolete inventory

111

1,135

Non-cash operating lease costs

10,296

7,866

Minimum accretion expense

97

109

PIK interest added to principal

1,674

8,839

Change in assets and liabilities

Accounts receivable(1)

(71,839

)

(63,199

)

Inventory

(2,160

)

(6,537

)

Prepaid expenses and other current assets

(6,997

)

(3,991

)

Investments and other assets

1,883

(16,700

)

Accounts payable

(49,250

)

(18,528

)

Related party asset

7,292

(25,000

)

Deferred revenue(2)

(24,107

)

17,398

Deferred other income(3)

(11,966

)

(11,966

)

Accrued data licensing fees

(3,180

)

3,730

Accrued expenses & other

58,493

(5,179

)

Interest payable

10,360

10,288

Operating lease liabilities

(10,762

)

(11,152

)

Net cash used in operating activities

$

(71,586

)

$

(181,302

)

(1) Includes increase in related party accounts receivable from Pathos AI, Inc. of $5,664 and $2,352 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 16, Related Parties. Includes increase in related party accounts receivable from SB Tempus Corp. of $145 and $108 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 7, Joint Venture.

(2) Includes decrease in related party deferred revenue from Pathos AI, Inc. of $3,835 for the nine months ended September 30, 2026. Includes increase in related party deferred revenue from Pathos AI, Inc. of $19,918 for the nine months ended September 30, 2025, respectively. Refer to Note 16, Related Parties. Also includes decrease in related party deferred revenue from SB Tempus Corp. of $6,235 and $18,737 for the nine months ended September 30, 2026 and 2025, respectively. Refer to Note 7, Joint Venture.

(3) Includes decrease in related party deferred other income from SB Tempus Corp. of $11,966 for each of the nine months ended September 30, 2026 and 2025. Refer to Note 7, Joint Venture.

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands)

Nine Months Ended
September 30,

2026

2025

Investing activities

Purchases of property and equipment

$

(23,665

)

$

(16,294

)

Proceeds from sale of marketable equity securities

—

8,316

Business combinations, net of cash acquired (Note 4)

(2,763

)

(375,025

)

Capitalized software costs

(12,252

)

(4,635

)

Net cash used in investing activities

$

(38,680

)

$

(387,638

)

Financing activities

Proceeds from convertible senior notes, net of initial purchasers' discount

443,132

726,497

Principal payments on long-term debt

(207,717

)

(276,892

)

Principal payments on revolving credit facility

(100,000

)

—

Prepayment premium on long-term debt

(6,433

)

(7,841

)

Payment of deferred offering costs

(264

)

(501

)

Purchases of capped call

(31,234

)

(41,775

)

Proceeds from revolving credit facility, net of original issue discount

—

98,000

Proceeds from long-term debt, net of original issue discount

—

196,000

Proceeds from issuance of common stock in connection with at-the-market offering, net of commissions

—

195,499

Payment of deferred financing fees

(1,349

)

(1,255

)

Net cash provided by financing activities

$

96,135

$

887,732

Effect of foreign exchange rates on cash

$

(86

)

$

(78

)

Net (decrease) increase in Cash, Cash Equivalents and Restricted Cash

$

(14,217

)

$

318,714

Cash, cash equivalents and restricted cash, beginning of period

609,451

341,835

Cash, cash equivalents and restricted cash, end of period

$

595,234

$

660,549

Cash, Cash Equivalents and Restricted Cash are Comprised of:

Cash and cash equivalents

$

590,479

$

655,918

Restricted cash and cash equivalents

4,755

4,631

Total cash, cash equivalents and restricted cash

$

595,234

$

660,549

Supplemental disclosure of cash flow information

Cash paid during the year for interest

$

15,111

$

37,349

Cash paid for income taxes

$

246

$

573

Preferred stock received on accounts receivable(4)

$

17,500

$

—

(4)

Includes related party preferred stock of Pathos AI, Inc. of $17,500 for the nine months ended September 30, 2026.

Tempus AI, Inc.

Condensed Consolidated Statements of Cash Flows

(Unaudited)

(in thousands)

Nine Months Ended
September 30,

2026

2025

Supplemental disclosure of noncash investing and financing activities

Purchases of property and equipment, accrued but not paid

$

10,226

$

3,724

Redemption of convertible promissory note

$

32,705

$

22,721

Deferred financing fees, accrued but not yet paid

$

—

$

489

Deferred offering costs, accrued but not yet paid

$

71

$

320

Reclassification of deferred offering costs to additional paid-in capital upon at-the-market offering

$

—

$

821

Operating lease liabilities arising from obtaining right-of-use assets

$

360

$

22,670

Capitalized software costs, accrued but not yet paid

$

21,536

$

—

Class A Common Stock issued in connection with business combinations

$

13,319

$

403,154

Class A Common Stock issued in connection with license agreement

$

—

$

1,443

Class A Common Stock issued in connection with holdback liability

$

6,173

$

—

Convertible promissory note principal reset due to amendment

$

—

$

72,488

Tempus AI, Inc.

RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL MEASURES

(Unaudited)

(in thousands, except percentages and per share amounts)

 

Diagnostics Gross Profit & Gross Margin

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Diagnostics revenue

$

303,470

$

252,878

$

853,901

$

688,525

Cost of revenues, diagnostics

114,042

98,643

323,235

283,182

Gross profit, diagnostics

$

189,428

$

154,235

$

530,666

$

405,343

Stock-based compensation expense

3,037

1,631

8,795

4,086

Employer payroll tax related to stock-based compensation

150

36

608

338

Non-GAAP gross profit, diagnostics

$

192,615

$

155,902

$

540,069

$

409,767

Diagnostics gross margin

62.4

%

61.0

%

62.1

%

58.9

%

Stock-based compensation expense

1.0

%

0.6

%

1.0

%

0.6

%

Employer payroll tax related to stock-based compensation

0.0

%

0.0

%

0.1

%

0.0

%

Non-GAAP gross margin, diagnostics

63.5

%

61.7

%

63.2

%

59.5

%

Data and applications Gross Profit & Gross Margin

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Data and applications revenue

$

108,067

$

81,328

$

288,238

$

216,053

Cost of revenues, data and applications

30,794

25,621

83,664

61,212

Gross profit, data and applications

$

77,273

$

55,707

$

204,574

$

154,841

Stock-based compensation expense

1,214

894

3,735

2,198

Employer payroll tax related to stock-based compensation

94

62

331

220

Non-GAAP gross profit, data and applications

$

78,581

$

56,663

$

208,640

$

157,259

Gross margin, data and applications

71.5

%

68.5

%

71.0

%

71.7

%

Stock-based compensation expense

1.1

%

1.1

%

1.3

%

1.0

%

Employer payroll tax related to stock-based compensation

0.1

%

0.1

%

0.1

%

0.1

%

Non-GAAP gross margin, data and applications

72.7

%

69.7

%

72.4

%

72.8

%

Total Gross Profit & Gross Margin

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Net revenue

$

411,537

$

334,206

$

1,142,139

$

904,578

Cost of revenues

144,836

124,264

406,899

344,394

Gross profit

$

266,701

$

209,942

$

735,240

$

560,184

Stock-based compensation expense

4,251

2,525

12,530

6,284

Employer payroll tax related to stock-based compensation

245

98

940

558

Non-GAAP gross profit

$

271,197

$

212,565

$

748,710

$

567,026

Gross margin

64.8

%

62.8

%

64.4

%

61.9

%

Stock-based compensation expense

1.0

%

0.8

%

1.1

%

0.7

%

Employer payroll tax related to stock-based compensation

0.1

%

0.0

%

0.1

%

0.1

%

Non-GAAP gross margin

65.9

%

63.6

%

65.6

%

62.7

%

Operating Expenses

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Technology research and development

$

45,708

$

38,087

$

135,558

$

105,960

Stock-based compensation expense

7,954

5,463

26,101

12,067

Employer payroll tax related to stock-based compensation

615

278

1,785

1,034

Non-GAAP technology research and development

$

37,139

$

32,346

$

107,672

$

92,859

Research and development

$

46,000

$

44,960

$

146,874

$

122,453

Stock-based compensation expense

5,432

3,301

15,284

7,618

Employer payroll tax related to stock-based compensation

274

122

1,005

533

Non-GAAP research and development

$

40,294

$

41,537

$

130,585

$

114,302

Selling, general and administrative

$

231,857

$

187,891

$

670,296

$

523,230

Stock-based compensation expense

30,437

22,690

100,986

53,439

Employer payroll tax related to stock-based compensation

1,615

541

4,071

6,040

Acquisition related expenses(1)

3,728

552

4,714

6,073

Amortization of intangibles due to acquisition

16,735

16,764

50,207

44,691

Franchise taxes related to IPO

—

—

—

1,647

Non-GAAP selling, general and administrative

$

179,342

$

147,344

$

510,318

$

411,340

Operating expenses

$

323,565

$

270,938

$

952,728

$

751,643

Stock-based compensation expense

43,823

31,454

142,371

73,124

Employer payroll tax related to stock-based compensation

2,503

941

6,860

7,607

Acquisition related expenses(1)

3,728

552

4,714

6,073

Amortization of intangibles due to acquisition

16,735

16,764

50,207

44,691

Franchise taxes related to IPO

—

—

—

1,647

Non-GAAP operating expenses

$

256,776

$

221,227

$

748,576

$

618,501

(1)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2026 and 2025.

Loss from Operations

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Loss from operations

$

(56,864

)

$

(60,996

)

$

(217,488

)

$

(191,459

)

Stock-based compensation expense

48,074

33,979

154,901

79,408

Employer payroll tax related to stock-based compensation

2,749

1,039

7,800

8,165

Acquisition related expenses(1)

3,728

552

4,714

6,073

Franchise taxes related to IPO

—

—

—

1,647

Amortization of intangibles due to acquisition

16,735

16,764

50,207

44,691

Non-GAAP income (loss) from operations

$

14,422

$

(8,662

)

$

134

$

(51,475

)

(1)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2026 and 2025.

Earnings per Share

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Net loss

$

(14,851

)

$

(79,982

)

$

(135,128

)

$

(190,862

)

Fair value changes(1)

(41,490

)

1,255

(107,750

)

(4,441

)

Stock-based compensation expense

48,074

33,979

154,901

79,408

Employer payroll tax related to stock-based compensation

2,749

1,039

7,800

8,165

Acquisition related expenses(2)

3,728

552

4,714

6,073

Amortization of intangibles due to acquisition

16,735

16,764

50,207

44,691

Losses (gains) from equity method investments

2,368

(1,518

)

8,318

2,465

Provision for (benefit from) income taxes

35

276

282

(45,692

)

Franchise taxes related to IPO

—

—

—

1,647

Amortization of technology license

(3,989

)

(3,989

)

(11,966

)

(11,966

)

Loss on debt extinguishment

—

12,034

11,643

12,034

Non-GAAP net income (loss)

$

13,359

$

(19,590

)

$

(16,979

)

$

(98,478

)

Non-GAAP net income (loss) per share, basic and diluted

$

0.07

$

(0.11

)

$

(0.09

)

$

(0.57

)

Weighted average common shares outstanding, basic and diluted

181,311

174,945

180,049

172,969

(1)

Fair value changes include gains and losses related to quarterly fair value adjustments of our marketable equity securities and indemnity-related holdback liabilities.

(2)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2026 and 2025.

Adjusted EBITDA

Three Months Ended
September 30,

Nine Months Ended
September 30,

2026

2025

2026

2025

Net loss

$

(14,851

)

$

(79,982

)

$

(135,128

)

$

(190,862

)

Interest income

(3,985

)

(4,600

)

(11,748

)

(7,506

)

Interest expense

6,701

15,399

31,325

54,981

Depreciation

7,338

8,120

21,888

24,350

Amortization

18,894

18,911

56,504

51,066

Provision for (benefit from) income taxes

35

276

282

(45,692

)

EBITDA

$

14,132

$

(41,876

)

$

(36,877

)

$

(113,663

)

Losses (gains) from equity method investments

2,368

(1,518

)

8,318

2,465

Fair value changes(1)

(41,490

)

1,255

(107,750

)

(4,441

)

Stock-based compensation expense

48,074

33,979

154,901

79,408

Employer payroll tax related to stock-based compensation

2,749

1,039

7,800

8,165

Acquisition related expenses(2)

3,728

552

4,714

6,073

Amortization of technology license

(3,989

)

(3,989

)

(11,966

)

(11,966

)

Franchise taxes related to IPO

—

—

—

1,647

Loss on debt extinguishment

—

12,034

11,643

12,034

Adjusted EBITDA

$

25,572

$

1,476

$

30,783

$

(20,278

)

(1)

Fair value changes include gains and losses related to quarterly fair value adjustments of our marketable equity securities and indemnity-related holdback liabilities.

(2)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2026 and 2025.

Investors
Kendra Webster
investorrelations@tempus.com

Media
Kelli Manalli
kelli.manalli@tempus.com

Source: Tempus AI, Inc.