United States securities and exchange commission logo November 29, 2021 Eric Lefkofsky Chief Executive Officer Tempus Labs, Inc. 600 West Chicago Avenue, Suite 510 Chicago, Illinois 60654 Re: Tempus Labs, Inc. Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted on October 28, 2021 CIK No. 0001717115 Dear Mr. Lefkofsky: We have reviewed your amended draft registration statement and have the following additional comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by providing the requested information and either submitting an amended draft registration statement or publicly filing your registration statement on EDGAR. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing the information you provide in response to this comment and your amended draft registration statement or filed registration statement, we may have additional comments. Consolidated Financial Statements Revenue Recognition, page F-14 1. We note your responses to prior comments 23 through 25. So that we may better understand your accounting for refreshes, please supplementally address the following: Explain in greater detail the nature of your performance obligations related to refreshes, including how they are defined and priced in your contracts with customers, the specific features and functionality refreshes provide, and the period of time over which you are required to provide refreshes. Tell us how you considered if these refreshes represent a stand-ready obligation to provide future products or services on a when-and-if-available basis. Explain the consequences, if any, if you do not provide refreshes to your customers. Eric Lefkofsky Tempus Labs, Inc. November 29, 2021 Page 2 You may contact Lisa Etheredge, Senior Staff Accountant, at (202)551-3424 or Robert Littlepage, Accounting Branch Chief, at (202)551-3361 if you have questions regarding comments on the financial statements and related matters. Please contact Kyle Wiley, Staff Attorney, at (202)344-5791 or Jan Woo, Legal Branch Chief, at (202)551-3453 with any other questions. Sincerely, FirstName LastNameEric Lefkofsky Division of Corporation Finance Comapany NameTempus Labs, Inc. Office of Technology November 29, 2021 Page 2 cc: Courtney Tygesson FirstName LastName